Go Back
Cat No: AH0001
Size
Price
Inventory
Number
20ul
$108.00
In stock
0
40ul
$200.00
In stock
0
100ul
$416.00
In stock
0
Add to Cart
Collectioned
Collection
Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
Main information
Target
PD1
Reactivity
Human
Applications
IHC,IF,ELISA
MW (kDa)
32kD（ Calculated）
56kD（ Observed）
Host Species
Mouse
Isotype
IgG1,Kappa
Detailed information
Reactivity
IHC 1:200-400
IF 1:200-1:1000
ELISA 1:500-5000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Validation Strategies
Specificity
The antibody can specifically recognize human PD-1 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
MW(Calculated)
32kD
MW(Observed)
56kD
Clonality
Monoclonal
Clone
M699V
Related products
GPX4 (R635P) Rabbit mAb
AR0001
Preview→
Nrf2 (R370G) Rabbit mAb
AR0002
Preview→
NF-κB p65 (R197I) Rabbit mAb
AR0003
Preview→
Mouse/Rabbit Tri-Labeling Four-Color Fluorescence Detection Kit
MH0001
Preview→
Antigen & target information
Immunogen:
Synthesized peptide derived from human PD-1 AA range: 1-100
Fold content
Gene Name:
PDCD1 PD1
Fold content
Protein Name:
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Fold content
Cell localization
Membranous, Cytoplasmic
Fold content
Tissue Expression
Fold content
Background
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
Fold content
Function
developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
Fold content
Research Areas
>> >>Cell adhesion molecules ;
>> >>T cell receptor signaling pathway ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer
>> >>T cell receptor signaling pathway ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer
Fold content
Signal Pathway
References（{{totalcount}}）
Filter by
Applications:
Reactivity:
Sort by:
Recently Viewed Products
Explore Our Recommended Popular Products
More products
30,000+ high- quality products available online
Primary Antibodies, Secondary Antibodies, mIHC Kits, ELISA Kits, Proteins, Molecular Biology Products，Cell Lines，Reagents ...
Contact Us
{{pinfo.title}}
-{{pinfo.catalog}}
Main information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Previous one
Next
{{pvTitle}}
Scroll
{{pvDescr}}
-
400-801-6722
-
support@lamarck.cn
-
Order
-
Message