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Cat No: AR0002
Size
Price
Inventory
Number
20ul
$120.00
In stock
0
40ul
$220.00
In stock
0
100ul
$452.00
In stock
0
Add to Cart
Collectioned
Collection
Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
Main information
Target
Nrf2
Reactivity
Human,Mouse,Rat
Applications
WB,IHC,IF,IP,ELISA
MW (kDa)
68kD（ Calculated）
100kD（ Observed）
Host Species
Rabbit
Isotype
IgG,Kappa
Detailed information
Reactivity
IHC 1:1000-1:5000
WB 1:2000-1:10000
IF 1:200-1:1000
ELISA 1:5000-1:20000
IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
MW(Calculated)
68kD
MW(Observed)
100kD
Clonality
Monoclonal
Clone
R370G
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Antigen & target information
Gene Name:
NFE2L2 NRF2
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Protein Name:
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)
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Alias:
Nuclear factor erythroid 2-related factor 2 ;
NF-E2-related factor 2 ;
NFE2-related factor 2 ;
HEBP1 ;
Nuclear factor, erythroid derived 2, like 2 ;
NF-E2-related factor 2 ;
NFE2-related factor 2 ;
HEBP1 ;
Nuclear factor, erythroid derived 2, like 2 ;
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Database link
Cell localization
Cytoplasmic, Nuclear
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Tissue Expression
Background
nuclear factor, erythroid 2 like 2(NFE2L2) Homo sapiens This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],
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Function
Domain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,Function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.,subunit:Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.,tissue specificity:Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.,
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Research Areas
>> >>Protein processing in endoplasmic reticulum ;
>> >>Parkinson disease ;
>> >>Pathways in cancer ;
>> >>Chemical carcinogenesis - reactive oxygen species ;
>> >>Hepatocellular carcinoma ;
>> >>Lipid and atherosclerosis ;
>> >>Fluid shear stress and atherosclerosis
>> >>Parkinson disease ;
>> >>Pathways in cancer ;
>> >>Chemical carcinogenesis - reactive oxygen species ;
>> >>Hepatocellular carcinoma ;
>> >>Lipid and atherosclerosis ;
>> >>Fluid shear stress and atherosclerosis
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Signal Pathway
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