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Cat No: AH0002
Size
Price
Inventory
Number
20ul
$108.00
In stock
0
40ul
$200.00
In stock
0
100ul
$416.00
In stock
0
Add to Cart
Collectioned
Collection
Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
Main information
Target
Sox-9
Reactivity
Human,Mouse,Rat,Bovine
Applications
IHC,ELISA
MW (kDa)
56kD（ Calculated）
70kD（ Observed）
Host Species
Mouse
Isotype
IgG2b,Kappa
Detailed information
Reactivity
IHC 1:200-400
ELISA 1:500-5000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Validation Strategies
Specificity
The antibody can specifically recognize human SOX9 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
MW(Calculated)
56kD
MW(Observed)
70kD
Clonality
Monoclonal
Clone
M777J
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Antigen & target information
Immunogen:
Synthesized peptide derived from human SOX9 AA range: 1-100
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Gene Name:
SOX9
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Protein Name:
Transcription factor SOX-9
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Cell localization
Nuclear
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Tissue Expression
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Background
SRY-box 9(SOX9) Homo sapiens The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008],
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Function
Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.,similarity:Contains 1 HMG box DNA-binding domain.,
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Research Areas
>> >>cAMP signaling pathway
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Signal Pathway
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