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Cat No: AR0001
Size
Price
Inventory
Number
20ul
$120.00
In stock
0
40ul
$220.00
In stock
0
100ul
$452.00
In stock
0
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Collectioned
Collection
Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
Main information
Target
GPX4
Reactivity
Human,Mouse,Rat
Applications
WB,IHC,IF,ELISA
MW (kDa)
22kD（ Calculated）
22kD（ Observed）
Host Species
Rabbit
Isotype
IgG,Kappa
Detailed information
Reactivity
IHC 1:200-1:1000
WB 1:2000-1:10000
IF 1:200-1:1000
ELISA 1:5000-1:20000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
MW(Calculated)
22kD
MW(Observed)
22kD
Clonality
Monoclonal
Clone
R635P
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Antigen & target information
Gene Name:
GPX4
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Protein Name:
GPX4
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Alias:
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial ;
PHGPx ;
Glutathione peroxidase 4 ;
GPx-4 ;
GSHPx-4 ;
PHGPx ;
Glutathione peroxidase 4 ;
GPx-4 ;
GSHPx-4 ;
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Cell localization
Cytoplasm
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Tissue Expression
Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016],
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Function
Catalytic activity:2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.,Disease:Defects in GPX4 may be a cause of infertility.,Function:Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.,similarity:Belongs to the glutathione peroxidase family.,subunit:Monomer. Has a tendency to form higher mass oligomers.,tissue specificity:Present primarily in testis.,
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Research Areas
>> >>Glutathione metabolism ;
>> >>Metabolic pathways ;
>> >>Ferroptosis
>> >>Metabolic pathways ;
>> >>Ferroptosis
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Signal Pathway
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