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Allograft rejection
Core of basic research: Explore the recognition mechanism of donor MHC antigens by the recipient's immune system, decipher the immune attack pathways mediated by T cells (CD4+/CD8+) and B cells, as well as the amplifying effect of cytokines (IL-2, IFN-γ) on rejection, providing targets for immunosuppressant development.
Core key proteins: MHC-I/II (donor antigens initiating rejection), TCR (T cell receptor recognizing MHC-antigen complexes), CD4+/CD8+ T cells (mediate cellular immune rejection), B cells/antibodies (mediate humoral immune rejection), TNF-α/IL-2/IFN-γ (pro-rejection cytokines), NF-κB (activates immune cells).
Core key proteins: MHC-I/II (donor antigens initiating rejection), TCR (T cell receptor recognizing MHC-antigen complexes), CD4+/CD8+ T cells (mediate cellular immune rejection), B cells/antibodies (mediate humoral immune rejection), TNF-α/IL-2/IFN-γ (pro-rejection cytokines), NF-κB (activates immune cells).
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