Rap1 signaling pathway
As a small GTPase of the Ras superfamily, Rap1 is an important molecule connecting cell surface receptors to downstream signal pathways, divided into two isoforms: Rap1A and Rap1B. Its activation depends on GTP binding mediated by GEF (e.g., C3G, Epac), and inactivation is regulated by GAP. Core functions include: regulating cell proliferation and survival by activating MAPK and PI3K-Akt pathways; enhancing cell-cell and cell-matrix adhesion through interactions with Cadherin and Integrin to maintain tissue integrity; participating in immune cell homing and vascular endothelial cell function regulation. Pathway abnormalities are associated with various diseases; for example, excessive activation of Rap1 promotes tumor cell migration and invasion, related to the metastasis of breast cancer and colorectal cancer; functional deficiency may lead to immunodeficiency diseases and cardiovascular diseases.
Core function: Regulate cell proliferation, adhesion, and differentiation by activating downstream pathways, maintaining tissue integrity and immune cell function. Key regulatory molecules: Rap1A/B, Raf, MEK, ERK, PI3K, Cadherin, Integrin.
Core function: Regulate cell proliferation, adhesion, and differentiation by activating downstream pathways, maintaining tissue integrity and immune cell function. Key regulatory molecules: Rap1A/B, Raf, MEK, ERK, PI3K, Cadherin, Integrin.
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