EGFR ERBB ERBB1 HER1

Epidermal growth factor receptor

EGFR ;
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in EGFR are associated with lung cancer [MIM:211980].,Function:Isoform 2/truncated isoform may act as an antagonist.,Function:Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin.,miscellaneous:Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.,online information:EGFR entry,PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.,PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1.,tissue specificity:Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.,

>> >>EGFR tyrosine kinase inhibitor resistance ;
>> >>Endocrine resistance ;
>> >>MAPK signaling pathway ;
>> >>ErbB signaling pathway ;
>> >>Ras signaling pathway ;
>> >>Rap1 signaling pathway ;
>> >>Calcium signaling pathway ;
>> >>HIF-1 signaling pathway ;
>> >>FoxO signaling pathway ;
>> >>Phospholipase D signaling pathway ;
>> >>Endocytosis ;
>> >>PI3K-Akt signaling pathway ;
>> >>Focal adhesion ;
>> >>Adherens junction ;
>> >>Gap junction ;
>> >>JAK-STAT signaling pathway ;
>> >>Regulation of actin cytoskeleton ;
>> >>GnRH signaling pathway ;
>> >>Estrogen signaling pathway ;
>> >>Oxytocin signaling pathway ;
>> >>Relaxin signaling pathway ;
>> >>Parathyroid hormone synthesis, secretion and action ;
>> >>Cushing syndrome ;
>> >>Epithelial cell signaling in Helicobacter pylori infection ;
>> >>Shigellosis ;
>> >>Hepatitis C ;
>> >>Human cytomegalovirus infection ;
>> >>Human papillomavirus infection ;
>> >>Coronavirus disease - COVID-19 ;
>> >>Pathways in cancer ;
>> >>Proteoglycans in cancer ;
>> >>MicroRNAs in cancer ;
>> >>Chemical carcinogenesis - receptor activation ;
>> >>Chemical carcinogenesis - reactive oxygen species ;
>> >>Colorectal cancer ;
>> >>Pancreatic cancer ;
>> >>Endometrial cancer ;
>> >>Glioma ;
>> >>Prostate cancer ;
>> >>Melanoma ;
>> >>Bladder cancer ;
>> >>Non-small cell lung cancer ;
>> >>Breast cancer ;
>> >>Hepatocellular carcinoma ;
>> >>Gastric cancer ;
>> >>Central carbon metabolism in cancer ;
>> >>Choline metabolism in cancer ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer