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Cat No: AR0103
Size
Price
Inventory
Number
20ul
$120.00
In stock
0
40ul
$220.00
In stock
0
100ul
$452.00
In stock
0
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Collectioned
Collection
Customized service consultation
Main information
Target
PCNA
Reactivity
Human,Mouse,Rat
Applications
WB,IHC,IF,IP,ELISA
MW (kDa)
29kD（ Calculated）
36kD（ Observed）
Host Species
Rabbit
Isotype
IgG,Kappa
Detailed information
Recommended Dilution Ratio
IHC 1:1000-1:4000
WB 1:1000-1:5000
IF 1:200-1:1000
ELISA 1:5000-1:20000
IP 1:50-1:200,
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
MW(Calculated)
29kD
MW(Observed)
36kD
Clonality
Monoclonal
Clone
R545Y
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Antigen & target information
Sequence:
ATLD2;cb16;Cyclin;DNA polymerase delta auxiliary protein;etID36690.10;fa28e03;fb36g03;HGCN8729;MGC8367;Mutagen-sensitive 209 protein;OTTHUMP00000030189;OTTHUMP00000030190;PCNA;Pcna/cyclin;PCNA_HUMAN;PCNAR;Polymerase delta accessory protein;Proliferating cell nuclear antigen;wu:fa28e03;wu:fb36g03
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Gene Name:
PCNA
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Protein Name:
Proliferating cell nuclear antigen
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Alias:
ATLD2 ;
cb16 ;
Cyclin ;
DNA polymerase delta auxiliary protein ;
etID36690.10 ;
fa28e03 ;
fb36g03 ;
HGCN8729 ;
MGC8367 ;
Mutagen-sensitive 209 protein ;
OTTHUMP00000030189 ;
OTTHUMP00000030190 ;
PCNA ;
Pcna/cyclin ;
PCNA_HUMAN ;
PCNAR ;
Polymerase delta accessory protein ;
Proliferating cell nuclear antigen ;
wu:fa28e03 ;
wu:fb36g03
cb16 ;
Cyclin ;
DNA polymerase delta auxiliary protein ;
etID36690.10 ;
fa28e03 ;
fb36g03 ;
HGCN8729 ;
MGC8367 ;
Mutagen-sensitive 209 protein ;
OTTHUMP00000030189 ;
OTTHUMP00000030190 ;
PCNA ;
Pcna/cyclin ;
PCNA_HUMAN ;
PCNAR ;
Polymerase delta accessory protein ;
Proliferating cell nuclear antigen ;
wu:fa28e03 ;
wu:fb36g03
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Database link
Cell localization
Nucleus
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Tissue Expression
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Background
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],
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Function
Disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,Function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,
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Signal Pathway
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