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Cat No: AB0532
Size
Price
Inventory
Number
20ul
$108.00
In stock
0
40ul
$200.00
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0
100ul
$416.00
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0
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Main information
Target
ROS1
Reactivity
Human,Mouse,Rat
Applications
IHC,IF
MW (kDa)
258kD（ Calculated）
258kD（ Observed）
Host Species
Rabbit
Isotype
IgG
Detailed information
Recommended Dilution Ratio
IHC 1:50-300
IF 1:50-300
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
Validation Strategies
Specificity
ROS1 Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
Concentration
1 mg/ml
MW(Calculated)
258kD
MW(Observed)
258kD
Clonality
Polyclonal
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Antigen & target information
Immunogen:
Synthesized peptide derived from human protein . at AA range: 2210-2290
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Gene Name:
ROS1 MCF3 ROS
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Protein Name:
Proto-oncogene tyrosine-protein kinase ROS (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
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Cell localization
Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression
Background
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],
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Function
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,Function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,
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